Sexual Problems and Depression If you are clinically depressed and also experiencing sexual problems, you're not alone. Sexual problems, such as erectile dysfunction (ED) or an inability to have an orgasm, often co-exist with depression . The good news is that doctors can usually treat sexual problems that are related to depression . What types of sexual problems are associated with antidepressants? Sexual problems with antidepressants may include: Inability to initiate or enjoy sex Erectile dysfunction (ED) or delayed ejaculation for men Decreased sexual desire Inability to achieve an orgasm How are sexual problems with depression or with antidepressants treated? If you have depression and are noticing a reduced interest in sex or problems with sexual functioning, it is important for you and your doctor to figure out if the cause of sexual dysfunction is the depression, the antidepressant you may be taking, or some other m...